Essay on Sophocles Clever Use of Dramatic Irony in...

Dramatic irony depends on the audience’s knowing something that the character does not, and in this play the audience knows Oedipus faith before he knows it himself. In this play there are several parts where Sophocles conveys his plot through dramatic irony. Dramatic irony underlines how partial human perceptive can be even when it is most reasonable and how agonizing it can be to be the costs of the misinterpretation, in some sense foreseeable. Dramatic irony is also use by Sophocles to make the audience feel their taken part of the play knowing the fate of the main character, making the audience wait in suspense wanting to know how Oedipus would react to his fate. The other use of the dramatic irony was to foreshadow which is a key†¦show more content†¦Since he has cursed himself the readers are in greater suspense. Blindness was another dramatic irony in the play, and relates to the entire play at large. Oedipus intelligence could not see the truth, but the blind man, Teiresias, saw it plainly. Sophocles uses blindness as a theme in the play. Oedipus was uninformed and as a result blind to the truth about himself and his past. Yet, when Teiresias exposes the truth he is in denial. It is left to Oedipus to conquer his blindness, accept the truth, and realize fate. But instead Oedipus ridicules Terirsias blindness and accuses him of being on the side of Kreon and helping him become King. He accuses Teiresias for being paid to tell a fraudulent prophecy to him. Quickly Teiresias answers him back and tells him he is BLIND, and tells him about his past of who his actual mother and father was. Which is ironic again because Oedipus fled his Corinth in hope that his prophecies of killing his father and marrying his mother would never happen not know who his actual parents was. When he left his home city of Corinth on his journey he kills a caravan of presumed low-class travelers. Which was h is faith in killing his father but in his mind he is thinking his father is King of Corinth. Oedipus is ignorant and does not try to learn and understand his past, but fate is fate so how doShow MoreRelatedThe Role of Fate in Oedipus the King Essay1051 Words   |  5 Pagesin the plays and literature of the Greeks as is shown in Sophocles play Oedipus Rex Sophocles lived during the Golden Age of Greece. He is renowned as one of the greatest dramaticist of western literature. He was a greek through and through as he held important political positions, and he even served as the priest of the haling diety Amynos. During his life tragedies were popular plays of the greeks, and Sophocles noted for his writing abilites of the time, made one suchRead MoreDeveloping Management Skills404131 Words   |  1617 Pagespermission should be obtained from the publisher prior to any prohibited reproduction, storage in a retrieval system, or transmission in any form or by any means, electronic, mechanical, photocopying, recording, or likewise. To obtain permission(s) to use material from this work, please submit a written request to Pearson Education, Inc., Permissions Department, One Lake Street, Upper Saddle River, New Jersey 07458. Many of the designations by manufacturers and seller to distinguish their products

Mixed Lineage Leukemia ( Mll ) - 1788 Words

Introduction Mixed lineage leukemia (Mll) are a family of catalytic enzymes in humans which contain a highly conserved SET domain required for their full catalytic activity (Dehe et al 2015). These family of proteins are involved in regulating gene expression by methylation of the 4th Lysine residue on H3 histones. So far, 6 different types of Mll family proteins have been identified in humans one of which is Mll1 (Morgan and Shilatifard 2013). The high number of Mll subunits observed in higher Eukaryotes is believed to be the result of high demand for regulating H3K4 methylation at chromatins (Zhang et al 2015). Mll1, the most studied member of these Mll family, is an enzyme in humans coded by KMT2A gene located on chromosome 11 (Zhang et†¦show more content†¦This demonstrates the urgency and need to study these family of proteins in effort to treat mixed lineage leukemia better. However, the large number of subunits and higher complexity of these family of proteins hinder the direct study of these proteins. Set1 is a yeast enzyme that is part of a large protein complex called COMPASS which also include Mll1 (Roguev et al 2001). Like Mll1, it also consist a highly conserved SET domain which 2 as catalytic role (Stassen et al., 1995; Laible et al., 1997). Moreover, these proteins share a similar function of regulating gene expression by mono-, di-, and tri-methylation of H3K4 (Amanika et al 2008). Thus, there exists a remarkable homology between Set1 and Mll1 proteins which allows indirect studies of Mll1 proteins. This is more ideal as Set1 is the only H3K4 methyl transferase in S.cerevisae which tremendously eliminate the complexity (Briggs et al 2001). In addition, loss of H3K4 methylation in S.cerevisae triggers apoptosis which allows better visualization of phenotypic growth differences (Walter et al 2014). Thus, studying Set1 can give important insight about Mll1 proteins and their mechanisms of action in causing leukemia. Set1 methyltransferases play an important role in gene silencing at silent chromatin regions of S.cerevisae. Silent chromatin regions are found at telomeres, HM loci (HML and HMR), and rDNA which are associated with low levels of transcription (Smith et al 1997). In previous

Economic Impact Of The Disease Health And Social Care Essay Free Essays

Whooping cough whooping cough is a contagious respiratory piece of land unwellness caused by a fastidious Gram negative coccobacillus, Bordetella whooping cough, or on occasion B. parapertussis ( Edmunds et al. , 2002 ) , with sole affinity for the mucosal beds of the human respiratory piece of land. We will write a custom essay sample on Economic Impact Of The Disease Health And Social Care Essay or any similar topic only for you Order Now It is a vaccinum preventable disease recognized world-wide as a extremely infective disease with important associated childhood morbidity, showing clinically as pneumonia, purging, choking enchantments, ictuss, encephalopathy and decease ( Galanis et al. , 2006 ; Health Canada, 2005 ; [ 2 ] . Globally, an estimated 50 million instances of whooping cough disease and 300,000 pertussis- related deceases occur yearly, largely among babies who are excessively immature to hold completed the primary inoculation series ( Halperin, 2001 ) . In the past decennary, an addition in the incidence has been observed in many developed states combined with a displacement in the incidence towards older age groups which may be related to increased consciousness, alterations in disease susceptibleness and vaccinum features, switching demographics, and familial fluctuations [ 2 ] . Although whooping cough is more terrible in babies and immature kids, the increasing incidence in striplings and grownups is a major concern as grownups are an of import beginning of transmittal to babies, infection in grownup cause ‘s important morbidity and high costs [ 3-5 ] . Stoping immunisation with whooping cough vaccinum in Sweden in a antecedently extremely immunised population resulted in the revival of the disease ( Mortimer 1988 ) . By 1994, an estimated 71 million whooping cough instances and 626 whooping cough deceases were being prevented worldwide each twelvemonth through immunisation ( Ivanoff A ; Robertson 1997 ) . In the absence of an immunisation programme 80 % of lasting neonates would get whooping cough in the first five old ages of life ( Fine A ; Clarkson 1984 ) . Due to concerns about safety and efficaciousness of whole-cell whooping cough vaccinum ( Romanus et al. , 1987 ) , diphtheria-tetanus-acellular whooping cough vaccinums ( DTPa ) were included in the Swedish inoculation plan at 3, 5 and 12 months of age in January 1996. Vaccination coverage quickly reached more than 98 % and an intensified clinical certification of reported laboratory-confirmed whooping cough in preschool kids started in October 1997. Sweden is a Norse state in Northern Europe, bordered by Norway on the West and Finland on the E, connected to Denmark by a bridge-tunnel across the Oresund. It is the 3rd largest state in the European Union by country, holding a entire population of about 9.5 million and population denseness of 21 dwellers per square kilometre. Whooping cough Incidence in Sweden before and after debut of noncellular whooping cough vaccinums The incidence rates of whooping cough after the debut of noncellular whooping cough vaccinum were markedly lower compared to before debut ( See graph 1 ) . The decrease of the incidence of whooping cough was most marked in the age groups covered by the three doses of DTPa at 3, 5, and 12 months of age ( 1-2-year-old in 1998 to 1-4-year-old in 2000 ) , with highest incidence happening among babies who were unvaccinated or had received merely 1 dosage of diphtheria-tetanus-acellular whooping cough vaccinum. The incidence among unvaccinated 0-2-month-old kids was 235 per 100,000 individual old ages compared to an mean incidence of 337 per 100,000 individual old ages in that age group during the 10-year period 1986-1995 before debut of DTPa ( RR 0.70, 95 % assurance interval ( CI ) 0.59-0.83 ) . In kids who had received merely one dosage of whooping cough vaccinum the incidence was 230 per 100,000 individual old ages and including all kids in the age group 3-4 months the incidence was 30 4 compared to an mean incidence of 677 per 100,000 individual old ages in that age group during 1986-1995 ( RR 0.45, 95 % CI 037-0.54 ) . A pronounced diminution of the reported incidence occurred after the 2nd and 3rd dosage of DTPa. After the 2nd dosage the incidence was 52 per 100,000 individual old ages. In to the full vaccinated kids ( three doses of DTPa ) the incidence was 11 per 100,000 individual old ages in kids below 2 old ages of age and 37 per 100,000 thereafter. Decreases were besides seen among older preschool-age kids, in the age groups 25-34 old ages of age and in the +35 age groups, but non among kids aged 7-19 old ages. Degree centigrades: Documents and SettingsAdministratorDesktopEdinburgh hebdomad 1ASSIGNMT 2Important also1-s2.0-S0264410X02007776-gr1.gif The one-year incidence of culture-confirmed B. whooping cough was 89-150 per 100,000 before debut of noncellular whooping cough vaccinums. After a rapid bead in 1996-1997 the overall one-year incidence reached 17-26 per 100,000 individual old ages. The overall incidence of notified culture- and polymerase concatenation reaction-confirmed whooping cough dropped from 113 to 150 per 100,000 during 1992-1995 to 11 to 16 per 100,000 during 2001-2004. In countries of enhanced surveillance, the incidence of whooping cough was 31 per 100,000 person-years after 2 doses and 19 per 100,000 person-years after the 3rd dosage at 12 months of age. The age-specific incidence remained low for about 5 old ages after the 3rd dose but increased in kids aged 6 to 8 old ages, going 32 and 48 per 100,000 person-years, severally. Hospitalization due to pertussis During the period of 1997-2000, there were 145 hospital admittances due to culture-confirmed whooping cough among kids born 1996 or subsequently, demoing an overall incidence of 18 hospitalizations per 100,000 individual old ages. Most of these kids were unvaccinated ( n = 116 ) , out of these, 97 including two deceases were below 3 months of age ( incidence 158 per 100,000 individual old ages below 3 months of age ) . There were 25 hospital admittances among kids with whooping cough who had received one dosage of DTPa ( incidence 61 per 100,000 ) , and four among kids above 5 months of age who had received two or more doses of DTPa ( incidence 0.6 per 100,000 ) . The continuance of infirmary stay was longer in the unvaccinated kids compared to the immunized kids: hospitalization for more than 1 hebdomad was seen in 49 % ( 57 of 116 hospital admittances ) among unvaccinated kids, compared to 24 % ( 6 of 25 ) among kids who had received one dosage of DTPa, and none among the four hosp italized kids who had received two or more doses of DTPa. Economic impact of the disease Whooping cough may be a drawn-out, terrible and awful disease ensuing in serious sequelae, doing a considerable hurt to both the kid and the household as a whole ( Johnston et al. 1985 ) . Due to the long- permanent class of the disease, the patients are exhausted, lose appetency and weight, and have disturbed dormant wonts. Behavioral alterations observed in whooping cough patients include crossness, anxiousness, and reverses in development ( Mark A ; Granstrom 1992 ) . The disease hence becomes a â€Å" household matter † ( Mortimer 1990 ) because of societal and economic effects for the stricken households. Episodes of choking, apnoea or cyanosis in sick kids are straitening events for the full household. A survey reported disturbed slumber for 78 % of parents, with 53 % holding to go to to the kid 4 times or more each dark ( Mark A ; Granstrom 1992 ) . The economic effects of the disease include disbursals for medical visits and drugs, and the demand to remain at place f rom work for a drawn-out period to take attention of the sick kid. Meanwhile the cost of a non-hospitalised instance of whooping cough in Sweden is non documented, some European states has been estimated at ?22 per visit ( Netton and Dennet, 1999 ) and a 10-day class of Erythrocin at ?4.40 ( eBNF-36 ) . Hospital stay due to pertussis would be on mean 5 yearss at ?297 ( Netton and Dennet, 1999 ) per twenty-four hours plus extra follow up GP audiences, numbering ?1529 per patient, once more, approximately 12.5 % of hospitalised instances require specializer attention, sing on mean 4 yearss pediatric ITU attention for complications of whooping cough at ?1065 per twenty-four hours ( www.doh.gov.uk/nhsexec/refcosts/refcost2000.pdf ) and 12 yearss general ward stay, numbering ?7868 ( Matt et al. , 2001 ) . In the 1980s, the hospitalization rate attributable to pertussis in Sweden was 12 to 18 per cent for all ages ) and the average continuance of infirmary stay was 8 yearss for babies you nger than 6 months, 6 yearss for kids 6-11 months of age, and 4 yearss for patients older than 12 months ( Romanus, Jonsell A ; Bergquist 1987 ) . Issues coming up Long-run effectivity of this inoculation plan showed increased incidence of whooping cough among 7- to 8-year-olds ( i.e. chiefly noncellular whooping cough vaccine-vaccinated kids ) . This shows waning of vaccine-induced protection from whooping cough. There is a attendant addition in incidence among babies, most probably infected by older siblings, hence inoculation schemes need to be reinforced. Expanded inoculation should hold included adding supporter doses to bing childhood agendas ( preschool or stripling ) ( Gustafsson et al. , 2006 ) . Vaccine boosting has had marked possible benefits in several European states, Canada and USA ( aˆÂ ¦aˆÂ ¦aˆÂ ¦aˆÂ ¦aˆÂ ¦.. ) . Attempts should be directed to increase or keep coverage of babies with three doses of DPT vaccinum at 90 per cent or higher. Surveillance of whooping cough morbidity should be strengthened and, ideally, whooping cough should stay a reportable disease. Inoculation agenda should hold besides included specific grownup subgroups that have the highest hazard of conveying B. whooping cough infection to babies ( i.e. , new parents, other contacts of neonates, and wellness attention workers ) . Reported informations based on hospitalized instances may endure from disproportional representation of terrible instances in younger kids and babies. During eruptions, describing rates may increase because of temporarily enhanced consciousness of doctors, anxiousness in the community, and media attending ( Crombie 1983 ) . Merely an approximately 5 to 25 per cent of all whooping cough instances are reported in Developed states ( Jenkinson 1983, Hinman A ; Koplan 1984, Clarkson A ; Fine 1985, Thomas 1989 ) and is disproportionately higher for hospitalized patients with authoritative, laboratory- confirmed disease ( Centers for Disease Control 1990 ) . Decision Meeting the GIVS ends would intend protecting kids against 14 diseases which include whooping cough among others. With 90 % of kids under-five old ages old vaccinated against whooping cough among others, by 2015 immunisation could forestall an extra two million deceases a twelvemonth in this age group, doing a major part to meeting MDG 4. While the impact on child deceases entirely would be sufficient justification for the usage of vaccinums, the decrease of long-run disablement among kids and the cost nest eggs from decrease in clinic visits and hospitalization more than warrant their usage in kids everyplace. By maintaining kids healthy, immunisation lengthens life anticipation and the clip spent on productive activity, and thereby contributes to a decrease in poorness ( MDG 1 ) . Harmonizing to Harvard School of Public Health squad â€Å" Healthy kids execute better at school and healthy grownups are both more productive at work and better able to be given to the wellness and ins truction of their kids. Healthy households are besides more likely to salvage for the hereafter ; since they tend to hold fewer kids, resources spent on them go farther, thereby bettering their life chances † ( Bloom et al. , 2005 ) . How to cite Economic Impact Of The Disease Health And Social Care Essay, Essay examples